Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as

Abstract

This study reviews the literature on the role of technology innovation in job creation through small businesses in developing countries. A sevenstep approach to the literature review is used for synthesising relevant data. The results show that technology innovations influence employment creation in small businesses positively and act as a driving force for economic development. The effective use of information technology in small businesses has a major impact on their competitiveness and access to international markets. Thus, the need for the government to develop technology innovative strategies for small businesses to actualise their firm performance and enhance job creation is recommended. The findings and proposed theoretical model of the study enrich existing theories and would help policymakers understand the role of information technology innovation in job creation and economic development.